Differin 0.1% Gel is a topical (applied to the skin) gel which contains the retinoid adapalene, the first over-the-counter active ingredient for acne in more than 30 years. Adapalene is a third-generation topical retinoid primarily used in the treatment of mild-moderate acne. Adapalene treats acne deep in the pores at the source, prevents new acne from forming and, as a result of reduced acne, restores your skin’s natural texture and tone. It may decrease the number and severity of acne pimples and promote quick healing of pimples that do develop.